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diagnosis treatment hematology differential lupus sle systemic barre encephalopathy guillain acquired activation anesthesia anesthesiology antibodies associations autoantibodies b1 blood bloodbank
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
Other brainstem syndromes ... (e.g. oculomotor ... Hypothalamic or thalamic syndromes ... AQP4-lgG disease; e.g ... , Sjögren syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Lumbar Puncture, EEG ... #SLE #CNS #neurology ... #rheumatology # ... cerebritis #diagnosis #management
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
activity Anti-Ro ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Periodic fever syndromes ... underlying disease (eg ... • Infection (eg ... hypersensitivity syndromes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... Endocrine disorders (e.g ... lymphoma • Evans' syndrome ... lymphoproliferative syndrome ... Shrinking lung syndrome
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
von Willebrand Syndrome ... Diagnosis and Management ... Lymphoproliferative disorders (e.g ... Myeloproliferative disorders (e.g ... vonWillebrand #Syndrome
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Anticentromere - CREST syndrome ... La) - Sjogren's syndrome ... - Vasculitis, e.g ... - Vasculitis, e.g ... Goodpasture's syndrome
Peri-operative Hyperthermia - Guidelines for Crises in Anaesthesia If prolonged or ≥ 39 C this is a
Neuroleptic malignant syndrome ... (e.g. haloperidol ... • Serotonin syndrome ... Anticholinergic syndrome ... Sympathomimetic syndrome
Wernicke Encephalopathy - Acute B1 (Thiamine) Deficiency - Diagnosis and Management Diagnosis - Caine Criteria (2 of
Diagnosis and Management ... dysfunctions ( e.g ... Cerebellar dysfunction (e.g ... development of Korsakoff syndrome ... #neurology #nutrition
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Hyperviscosity Syndrome ... Cryoglobulinemia Syndrome ... cryoglobulinemia syndrome ... 20% Sjögren's syndrome ... tissue disorder (e.g
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