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differential management pain signs systemic arthritis erythematosus lupus oncology syndrome vasculitis apml bone causes classification comparison conditions differentiation disease extrarticular
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... effusion, Restrictive lung ... phenomenon (20%) Joints ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Interstitial lung ... • Pulmonary ... • Shrinking lung ... #differential #diagnosis ... #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... constitutional symptoms ... (tuberculosis) ... arthritis • SLE ... #MSK #rheumatology
Causes of Bone/Joint Pain in Sickle Cell Disease Vaso-occlusive pain: • Mechanism: ischemic pain • Can present
Causes of Bone/Joint ... Generally affects long ... dz difficult to see ... #differential #diagnosis ... #causes #hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
(interstitial lung ... Musculoskeletal: joint ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Arthritis: • Joint ... arthropathy • 90% joints ... Induced Lupus: • Symptoms ... #Rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
ARDS to explain symptoms ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology ... #diagnosis #comparison
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... common • Imaging: CXR ... - pulmonary opacities ... >3 symptoms, or> ... #management #hematology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
acute respiratory symptoms ... symptoms • Rheumatologic ... muscle aches, joint ... change in the lungs ... nails, bronchi, lungs
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... bone pain, fever, joint ... manifestations, hypoxia, CXR ... #Leukemia #Hematology ... #Oncology #Diagnosis
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