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differential oncology management signs systemic arthritis classification erythematosus infectiousdiseases leukemia lupus pain sle vasculitis algorithm approach autoantibodies autoimmune cancer chronic
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
- pulmonary opacities ... >3 symptoms, or> ... : Infection (sepsis ... ), PE, DAH, CHF, ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
bone pain, fever, joint ... manifestations, hypoxia, CXR ... smear: Blasts APML ... #Leukemia #Hematology ... #Oncology #Diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
(interstitial lung ... Musculoskeletal: joint ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #workup
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
or nerve root Symptoms ... Calcium oxalate Infectious ... #Pain #MSK #rheumatology ... #approach #workup ... #differential #diagnosis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... Myositis 4% - Lung ... Other auto-immune, Infectious ... autoantibodies #signs #symptoms ... #differential #rheumatology
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
ARDS to explain symptoms ... : Age>60, CKD, CHF ... fluid balance, and CXR ... with pulmonary ... Transfusion #Reactions #hematology
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
symptoms • Rheumatologic ... muscle aches, joint ... MC: CNS CSF: • ... change in the lungs ... nails, bronchi, lungs
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Bacterial or viral infection ... • Interstitial lung ... • Shrinking lung ... #differential #diagnosis ... #rheumatology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
massiliense in CF ... Hematologic malignancy ... gastrointestinal symptoms ... Diagnosis Of NTM ... • Clinical (Symptoms
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... Malignancy • Infections ... thrombophlebitis, pulmonary ... #rheumatology # ... hematology
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