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pharmacology management diagnosis candida treatment infectiousdiseases antibiotics antibiogram clinical fungal infections medications overview review table candidiasis dermatology differential idsa sensitivities
Antifungal Coverage Activity Antibiogram Spectrum of action of systemic antifungal agents. Solid blocks represent species in
Antifungal Coverage ... action of systemic antifungal ... species in which the antifungal ... PMC3146381/ #Antifungal ... Triazoles #Polyenes #Echinocandins
Antifungal Echinocandins - Antibiotics Class Overview Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... monotherapy) All Echinocandins ... Review #Overview #Echinocandins ... #Antifungal #Caspofungin
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and
Antifungal Polyenes ... infections – because echinocandins ... Overview #Polyenes #Antifungal
Invasive Candidiasis (IC) Diagnosis: Culture: • Gold standard, but Slow (~2-3 days), 50% sensitivity • Blood Sample •
Tests Conduct antifungal ... with AFST) • Echinocandin ... Candidiasis #IC #antifungal
Candida Glabrata Species of Candida Most Commonly Isolated in Bloodstream Infections • Symptomatic mucosal infection is detected
unresponsiveness to antifungal ... time to azole antifungals ... option, consider echinocandin
Spectrum of activity for systemic antifungal agents Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... .2015.10.012 #Antifungal
Tinea Versicolor (Pityriasis versicolor) NOT a dermatophyte infection Caused by saprophytic, lipid-dependent yeasts Clinical •
Management • Topical antifungals ... • Oral antifungal
Common toxicities of antifungal agents. CNS = central nervous system; 5-FC = flucytosine; GI = gastrointestinal;
toxicities of antifungal ... #antifungal #toxicities
Rare Invasive Yeasts - Species and Antifungal Therapy Cryptococcus, Geotrichum, Kodamaea, (Pichia)ohmeri, Malassezia, Pseudozyma, Rhodotorula, Saccharomyces, Saprochaete
- Species and Antifungal ... Invasive #Yeasts #Antifungal
Antibiotics and CNS Diffusion 1. Drugs with good CNS diffusion: - Fluoroquinolones, Fluconazole, voriconazole, Rifampin, Oxazolidinones, Metronidazole 2. Drugs
infections: - Echinocandins
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