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diagnosis algorithm rheumatology hepatology differential dermatology gastroenterology oncology pharmacology disease neurology nephrology vasculitis table causes comparison guidelines medications indications hepatitis
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
organ damage • Treatment ... Low calcium • Treatment ... - Hyperkalemia treatment ... TLS #diagnosis #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... >500 ng/mL • Elevated ... • Bicytopenia Treatment ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... if WBC > 5 or elevated ... APML #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... hyperinflammatory syndrome ... Hyperferritinemia - Elevated ... Elevated soluble ... #Hematology #HemeOnc
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
Hypereosinophilic Syndrome ... suspect underlying hematologic ... Diagnosis and Treatment ... #HES #Hematology ... eosinophils #diagnosis #management
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated ... → Refer to hematology ... • Nonmalignant hematologic ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... Diagnosis and Management ... only curative treatment ... Myelodysplastic #Syndrome ... #treatment #hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Elevated Transaminases ... Vascular: Budd-chiari syndrome ... Sinusoidal obstruction syndrome ... Transaminitis #Elevated ... Diagnosis #causes #hepatology
End Stage Liver Disease (Cirrhosis) - Complications • Ascites • Esophageal Varices • Hepatic
Hepatopulmonary Syndrome ... • Hepatorenal Syndrom ... Complications #diagnosis #management ... #summary #hepatology
Genital Lesions - Differential Diagnosis Algorithm Elevated - Vesicles: • Herpes simplex Elevated - Papules / Plaques -
Diagnosis Algorithm Elevated ... Herpes simplex Elevated ... ) • Reiter's syndrome ... ) • Behcet's syndrome ... #skinlesions #dermatology
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