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diagnosis hematology syndrome acquired adultonset algorithm apml chronic classification cll differentiation encephalopathy hemeonc hemophagocytic hlh hodgkins leukemia lymphocytic lymphohistiocytosis lymphoma
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Thrombocytosis - Elevated ... Platelet Count - Differential ... Rebound effect from treatment ... Malignancy: Metastatic cancer ... Vasculitides, IBD, Celiac disease
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... fraction < 20% Differential ... hemopathies, solid cancers ... #diagnosis #management ... #treatment #rheumatology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Diagnosis and Management ... thrombocythemia), Autoimmune disease ... adsorption onto cancer ... #treatment #hematology ... #differential
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Leukemia - Summary Cancer ... cells can indicate disease ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... if WBC > 5 or elevated ... initiation • Differential ... APML #diagnosis #management ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Inflammatory marker elevated ... Immunohistochemical studies (to differentiate ... number of sites of disease ... Hodgkin Lymphoma Treatment ... #oncology #management
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Shock, Autoimmune disease ... , Cancer chemotherapy ... Reversible course Differential ... An elevated white ... Syndrome #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
it is often a cancer ... ▪ Autoimmune diseases ... Hyperferritinemia - Elevated ... Elevated soluble ... #Hematology #HemeOnc
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