46 results
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Photosensitivity, Butterfly rash ... Cranial nerve lesions ... , Aortic valve lesions ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... • SLE • Human ... Discoid skin lesions ... differential #diagnosis #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
• Urogenital Lesions ... ) • Cutaneous Lesions ... Oral aphthae : SLE ... • Arthritis: SLE ... #rheumatology #
Herpes Zoster Mandibularis - The lesions were scattered along the area that is innervated by the
Mandibularis - The lesions ... #Clinical #Photo ... #Mandibularis #Rash
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... NPSLE rare, Malar rash ... constitutional symptoms ... #comparison #table ... #rheumatology #
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Lupus (SLE): Mucocutaneous ... scaly annular lesions ... plugging -> Discoid Rash ... Malar (butterfly) Rash ... diagnosis #signs #symptoms
Management of Lupus Nephritis
Lupus nephritis (LN) in 10 to 40% of SLE
Hallmark = proteinuria 20.5 g/g
in 10 to 40% of SLE ... active and chronic lesions ... (C) : chronic lesions ... IV (A) : active lesions ... (C) : chronic lesions
Stages of Syphilis
Early Primary:
 • Painless chancre
 • Regional lymphadenopathy
Early Secondary:
 • Fever, malaise
 • Rash
Fever, malaise • Rash ... testing • No symptoms ... Gummatous • Nodular lesions ... Syphilis #Stages #symptoms
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
vasculitis Skin lesions ... • Painful skin lesions ... Papulo-necrotic lesions ... reticularis • Necrotic lesions ... gangrene Skin lesions
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... can present with rash ... including heliotrope rash ... Can also see mechanics ... Myositis #diagnosis #rheumatology