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diagnosis management differential causes classification disorders leukemia blood hepatology apml basophilia basophils cancer cml differentiation endocrinology eosinophilia essential et gastroenterology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... , CLL Acute leukemias ... ALL (Acute Lymphoblastic ... involvement CML ... ↓ LAP Score • CML
Map of proliferative blood disorders. By Ariella Coler-Reilly @ariellastudies #Algorithm #classification #proliferative #blood #disorders #leukemia #hematology #oncology
ariellastudies #Algorithm ... disorders #leukemia #hematology ... #oncology #diagnosis ... #CML #CLL #AML
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Acute • Myloid ... (AML) - CD13, CD33 ... - CD7, CD3 Chronic ... • Lymphoid (CLL ... CD23, o CML
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Lymphoblastic Leukemia (ALL ... ) • Acute ... Myeloid Leukemia (AML ... ) • Chronic ... Myeloid Leukemia (CML
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... microglobulin Treatment ... ’s lymphoma or acute ... diagnosis #workup #oncology ... #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... hemorrhage) • Chronic ... Myelofibrosis (MF) • Chronic ... myeloid leukemia (CML ... Diagnosis #Causes #hematology
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Disorders: • Chronic ... myeloid leukemia (CML ... translocation • Acute ... thrombocythemia • Acute ... Diagnosis #causes #hematology
Hepatitis B - Treatment Indications Treatment not indicated: • Immune tolerant state - HBe-Ag detectable, high HBV
DNA (>10^6 IU/mL ... DNA (<2000 IU/mL ... DNA (>10^6 IU/mL ... DNA > 2000 IU/mL ... DNA > 2000 IU/mL
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... • Induce blast cell ... Renal Failure Treatment ... diagnosis #management #hematology ... #oncology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
Primary: - CML ... Mastocytosis - Acute ... Hypereosinophilic Syndrome - Chronic ... Diagnosis #Causes #hematology
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