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diagnosis differential nephrology hematology erythematosus lupus sle systemic treatment algorithm dermatology low summary vasculitis abg acid acidbase ana anca antibodies
BEE Syndromes - Immune-mediated conditions affecting the brain, eye, and ear Visual or auditory symptoms in conjunction
and less common diseases ... Inflammatory causes ... • Sjögren syndrome ... optica spectrum disorder ... #neurology #inflammatory
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... Kasabach-Merritt syndrome ... Gardner-Diamond syndrome ... Associated - SLE, Sjogren's ... #rheumatology #
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Causes of Hypocomplementemia ... Chain deposition disease ... autoimmune (RA, Sjogren's ... antiphospholipid syndrome ... Erythematosus (total 50, renal
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
& renal involvement ... heart block • Sjogren ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
• Sjögren syndrome ... polyangiitis without renal ... ANCA+ 30-60% • Renal-limited ... antibodies #diagnosis #rheumatology ... #diseases
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... • Autoimmune diseases ... RA - 5 to 20% Sjögren's ... classification #rheumatology
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... (AQP4-lgG disease ... Comorbid autoimmune disorders ... erythematosus, Sjögren ... Manifestations #diagnosis #neurology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... #Syndrome #Rheumatology ... #Diagnosis #Management
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #rheumatology # ... cerebritis #diagnosis #management
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Causes of Acute ... Tuberculosis Whipple disease ... Procainamide Metabolic disorders ... : Renal Insufficiency ... Collagen vascular disease
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