13 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... • Sjögren syndrome ... Jcortesizaguirr #ANA ... antibodies #diagnosis #rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antibody refers ... ), Sjogren's Syndrome ... Syndrome, Myositis ... Lymphoproliferative Disorders ... #patterns #rheumatology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Cryoglobulinemia (MIXED) • ANCA ... Associated - SLE ... , Sjogren's ... Differential #Diagnosis #hematology ... #rheumatology #
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Antinuclear (ANA ... & renal involvement ... heart block • Sjogren ... Summary #diagnosis #rheumatology ... #management
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... • Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... cytoplasmic antibody ... classification #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
dermatomyositis, Sjogren ... syndrome, and mixed ... APLA/LAC: • Renal ... Serositis Labs: • ANA ... Erythematosus #Diagnosis #Rheumatology
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Evaluate for NMO, SLE ... or Sjogren's ... - Sjogren - ... Myelitis #diagnosis #management ... #neurology #differential
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #CNS #neurology ... #rheumatology #
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... overlaps with RA, SLE ... Distal (Type I) renal ... #Syndrome #Rheumatology ... #Diagnosis #Management
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
Spinal Cord Disorders ... Causes: 1. ... - SLE, Scleroderma ... syndrome Cord ... #diagnosis #neurology