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diagnosis algorithm differential nephrotic workup nephritic proteinuria renal blood glomerulonephritis syndrome testing urine urology alkalosis biopsy classification comparison contraindications disease
Hematuria - Differential Diagnosis Framework Gross Hematuria: Red/Dark urine • 1ml blood/liter urine can induce color change
or dipstick) Glomerular ... of Glomerular Bleeding ... • Signs of glomerular ... Suggestive of glomerular ... #urology #nephrology
Causes of Hematuria - Differential Diagnosis Algorithm Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... • Calculi Glomerular ... with active sediment ... with active sediment ... Diagnosis #Algorithm #Causes
Nephritic vs Nephrotic Syndrome Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes. Step
the patient has hematuria ... the patient have glomerular ... hematuria (RBC ... casts or dysmorphic ... Comparison #Algorithm #Nephrology
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... • Evidence of glomerular ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology ... if cause not identified
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome—due to GBM disruption. Hypertension. t BUN and creatinine.
Glomerular Diseases ... hematuria. ... RBC casts in urine ... diabetes)) #Glomerular ... #Proteinuria #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
Causes of Proteinuria ... • Drugs Glomerular ... albuminuria) - Active ... #Proteinuria #Nephrology ... Diagnosis #Algorithm #Causes
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
presenting with overt glomerular ... Cytomegalovirus; GBM = glomerular ... Nephrocalcinosis causes ... Hematuria may be ... nephrotic #syndrome #nephrology
Recommended initial testing for patients being evaluated for glomerular disease 24-hour urine collection - Quantify proteinuria.
evaluated for glomerular ... disorders that activate ... infections are common causes ... of glomerular disease ... nephrotic #nephritic #nephrology
Renal Biopsy - Absolute and Relative Contraindications WHEN NOT TO DO IT: • Isolated glomerular hematuria, unless
: • Isolated glomerular ... hematuria, unless ... proteinuria unless hematuria ... bilateral cysts • Active ... Contraindications #management #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Mesangiocapillary GN • Active ... dysmorphic RBC, RBC casts ... formation along glomerular ... Glomerulonephritis #MPGN #nephrology
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