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hematology rheumatology differential management oncology pathophysiology vasculitis manifestations sle allergy anaphylaxis classification complications erythematosus systemic activation algorithm alopecia anemia aplastic
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... Malar (butterfly) Rash ... decr release and activity ... pathophysiology #diagnosis ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Photosensitivity, Butterfly rash ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... extremity edema, active ... : • Symptoms limited ... CRP normal, ESR active ... Erythematosus #Diagnosis
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
- Rash: multiple ... Episcleritis Signs ... Causes: - Idiopathic ... - Lupus - Leukemia ... #diagnosis #dermatology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... increased B-cell activity ... are not caused ... skin (16-32%): lupus ... #Management #Signs
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... purpura to mucosal bleeding ... Petechial or purpuric rash ... SJIA], systemic lupus ... #Diagnosis #Management
Neuromyelitis Optica (NMO) - Clinical Manifestations • Optic neuritis: Reduced visual acuity, ranging from mild to
involvement: Intractable nausea ... disorders (Systemic lupus ... Manifestations #diagnosis ... #neurology #symptoms ... #signs
Clinical manifestations of anaphylaxis. Neurological (<15%): Dizziness, syncope, seizures, Confusion, impending doom. headache Angioedema: Lips, tongue, orbit,
arrest, Kounis syndrome ... arrest GI (>40%): Nausea ... cramps, vaginal bleeding ... #anaphylaxis #signs ... #symptoms #diagnosis
Secondary Syphilis Rash Secondary syphilis is the most contagious of all the stages of this disease, and
Secondary Syphilis Rash ... The signs and symptoms ... resembling rashes caused ... #Diagnosis #Clinical ... #Photo #Dermatology
Papulosquamous Skin Rash - Differential Diagnosis Algorithm Erythrematous or violaceous papules & plaques with overlying scale •
Papulosquamous Skin Rash ... Auspitz sign, Koebner's ... soles • Discoid Lupus ... Papulosquamous #SkinRash #dermatology ... #Algorithm #causes
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