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diagnosis management differential erythematosus hematology hemophagocytic hlh immune iris lupus lymphohistiocytosis neurology reconstitution sle systemic treatment associated bandemia cbc cerebritis
Immune Reconstitution Inflammatory Syndrome (IRIS) - Pathophysiology Risk factors: - Low CD4 count - Disseminated OI -
Syndrome (IRIS) ... - Pathophysiology ... factors: - Low CD4 ... #Syndrome #IRIS ... #AIDS
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE) Clinical ... Demyelinating Syndrome ... Disease, PRES Pathophysiology ... Treatment: • Inflammatory ... CNS #neurology #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... production of pro-inflammatory ... accumulation of clinical ... treatment #summary #rheumatology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
Syndrome - Overview ... treatment of HIV/AIDS ... be present: • AIDS ... noncompliance • Clinical ... initiation Clinical
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... abnormalities • Inflammatory ... likelihood of negative clinical ... neutrophil #WBC #CBC ... #hematology #pathophysiology
HIV-Associated Neurocognitive Disorder (HAND) Definition: HIV-Associated Neurocognitive disorders categories: • Asymptomatic neurocognitive impairment • Mild neurocognitive impairment • HIV dementia Pathophysiology: HIV frequently
HIV dementia Pathophysiology ... Clinical Presentation ... : The clinical ... syndrome of HAD ... disorder #dementia #AIDS
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... photosensitivity, inflammatory ... Non-autoimmune rheumatologic ... Clinical Features ... titers > 1:80 • CBC
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... has five major clinical ... yeast • At risk: AIDS ... Aspergillosis Pathophysiology ... ) #Mycoses #InfectiousDiseases
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Clinical Presentation ... Pathophysiology ... of NK cells and CD8 ... Overproduction of pro-inflammatory ... Diagnosis #Management #Hematology
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