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differential hematology management erythematosus lupus sle anemia symptoms allergy causes hodgkins hypersensitivity lymphoma myositis oncology reactions table vasculitis agglutinin aiha
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... : • Autoimmune ... #Differential #Diagnosis ... #Algorithm #hematology
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Warm Antibody Autoimmune ... 1) DIAGNOSE AIHA ... Coombs • IgG type ... FOR a cause → Systematic ... #treatment #rheumatology
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
surfaces • Ex: Autoimmune ... Hemolytic anemia ... complexes • Ex: Systemic ... #Classification ... #Diagnosis #Definitions
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table Warm AIHA (48-70%) Cold AHA (16-32%) • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... - Differential Diagnosis ... Disease Mixed-type ... #Hemolytic #Anemia ... #Table #hematology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
- Local and systemic ... or during hemolytic ... arthritis, and systemic ... #Classification ... Pathophysiology #Allergy #Diagnosis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
- Differential Diagnosis ... Inflammatory and Autoimmune ... Diseases: • Systemic ... Antibody-mediated hemolysis ... #Hematology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Systemic Sclerosis ... autoimmune disease ... skin thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
EULAR/ACR Classification ... Thrombocytopenia, Autoimmune ... hemolysis • Renal ... Erythematosus #diagnosis ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... infection • Autoimmune ... Labs/Diagnosis: ... #types #classification ... #rheumatology #
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... normochromic nomocytic or haemolytic ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
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