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hematology differential algorithm causes oncology treatment atlas macrocytic morphology product reactions aafp abscess agglutinin antibody aplastic autoimmune bandemia bloodcell calculation
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... ↑ LDH • Anti-RBC ... type ± C3d • Blood ... #Anemia #diagnosis ... #management #treatment
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... Microangiopathic Hemolytic ... #differential #diagnosis ... #hematology #microscopy
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... in peripheral blood ... High in acute blood ... loss, hemolysis ... #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... #Anemia #Differential ... #Diagnosis #Algorithm ... #workup #hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Microangiopathic hemolytic ... RBC defects (e.g ... Production #Index #hematology ... #diagnosis #calculation
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... spherocytosis, Hemolytic ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Diagnosis Framework ... Defects: Sickle cell anemia ... - Peripheral Blood ... #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... of Peripheral blood ... schistocytes, nucleated RBCs ... anemia Indirect ... #Workup #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... anemia • Cold ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.) Physicians
(RBC = red blood ... Hemorrhage or hemolysis ... of the initial work-up ... #Diagnosis #Macrocytosis ... Homocysteine #Algorithm #Workup
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