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differential syndrome druginduced lupus treatment vasculitis activation ana anca anemia antibodies antibody antineutrophil antinuclear aplastic behcet classification comparison conditions dil
Hypereosinophilia Syndrome (HES) - Diagnosis and Management Definition: An absolute eosinophil count (AEC) greater than 1500 and
Syndrome (HES) - Diagnosis ... and Management ... Allergic disorders - Drug ... #diagnosis #hematology ... #differential #management
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease Mild: • Trial of PPI • Trial
Eosinophilic Gastroenteritis ... Concern for HES: • Hematology ... • Additional diagnostic ... as CT scan #EoE ... Gastroenteritis #Treatment #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Drug Induced Lupus ... vs SLE Drug Induced ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
Anti-histone (in drug-induced ... SLE) • Systemic ... ANCA+ 60% • Eosinophilic ... Antineutrophil #antibodies #diagnosis ... #rheumatology #
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
Joint Pain Eyes ... retinal exudates) - SLE ... Amyloidosis • Eosinophilic ... #differential #diagnosis ... #rheumatology
Drug Induced Systemic Lupus Erythematosus > 100 drugs have been associated with drug-induced SLE High risk (>5%): •
SLE High risk ... #DrugInduced #SLE ... #pharmacology # ... #differential #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
erythematosus [SLE ... ) • Sepsis • Drug-induced ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
: Inflammatory eye ... Oral aphthae : SLE ... • Arthritis: SLE ... #management #signs ... #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Autoimmune diseases: SLE ... immune deficiency, Drugs ... #management #treatment ... #summary #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• EGPA: - Eosinophilia ... Arthralgias • Eye ... Eye -> retinopathy ... vasculitis, and SLE ... #rheumatology #
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