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Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Prolonged PT and aPTT ... #Abnormal #PT #aPTT
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... , FVII, FIX, FX ... , FVII, FIX, FX) ... #Abnormal #PT #aPTT
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
PT - Prolonged aPTT ... PT - Prolonged aPTT ... Coagulation #Abnormal #APTT ... #Laboratory #Hematology
How to Evaluate an Abnormal APTT
Step 1: Is the PT or APTT Artifactually Prolonged?
Step 2: Is
Evaluate an Abnormal APTT ... : Is the PT or APTT ... Prolonging the PT or APTT ... cause of Prolonged APTT ... ISNeducation #Abnormal #APTT
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... warfarin) • Factor VII ... Thromboplastin Time (PTT ... thematttsai #PT #PTT ... Thromboplastin #laboratory
Effect of Anticoagulants on Coagulation Tests
PT / INR, aPTT, Anti-Xa Activity, Activated Clotting Time, Thrombin Time,
Tests PT / INR, aPTT ... Testing #Diagnosis #Laboratory
Approach to Elevated aPTT / PT - Differential Diagnosis Algorithm

aPTT: Intrinsic / Final
PT: Extrinsic / Final

By
Approach to Elevated aPTT ... Diagnosis Algorithm aPTT ... #Elevated #aPTT
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
GI. uterine) Laboratory ... INR • Normal aPTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
• Prolonged PT/PTT ... levels of factors VII ... venipuncture sites Laboratory ... PT/INR: ↑ • PTT ... INR < 2.3 - APTT
Prolonged APTT - Diagnostic Algorithm

#Prolonged #APTT #PTT #abnormal #Diagnosis #Algorithm #hematology
Prolonged APTT - ... #Prolonged #APTT ... #PTT #abnormal