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diagnosis management differential hepatology rheumatology treatment neurology algorithm causes lfts coagulation liver pt transaminitis abnormal cranialnerve oncology pathophysiology syndrome workup
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
deficiency of FVII ... deficiency of FVII ... inhibitors to FVII ... , FVII, FIX, FX ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
, FVII, FIX, FX ... production Fll, FV, FVII ... , FIX, FX, FXII, ... , FVII, FIX, FX) ... #differential #hematology
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Phosphatase, ALT ≥ 3x ULN ... Transaminase, ALP ≥ 2x ULN ... Value = (ALT / ULN ... ALT) / (ALP / ULN ... Transaminitis #diagnosis #hepatology
Cranial Nerve Nuclei - Cross Sectional Anatomy CN III - Oculomotor Nerve CN IV - Trochlear Nerve CN V
Sectional Anatomy CN ... Trochlear Nerve CN ... Abducens Nerve CN ... VII - Facial Nerve ... Nerve CN IX -
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Severe ALT > 15x ULN ... Moderate ALT 5-15x ULN ... Mild ALT < 5x ULN ... Others #LFTs #Hepatology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
value = (ALT + ULN ... phosphatase + ULN ... #differential #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis Hepatocellular Pattern (ALT or AST > ALP):
Severe - ALT >15X ULN ... Moderate - ALT 5-15X ULN ... Mild - ALT < 5x ULN ... Algorithm #diagnosis #hepatology
Types of Facial Paralysis - Peripheral vs Central Lesions Facial weakness or paralysis may result either from
peripheral lesion of CN ... VII, the facial ... peripheral lesion of CN ... VII, exemplified ... #CNVII #CN7 #Peripheral
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Lymphadenopathy, CNS ... - T-cell - CD7 ... Blood #Disorders #hematology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
CK: Up to 50X ULN ... CK: Up to 50X ULN ... Proximal • CK: >50X ULN ... CK: Up to 10x ULN ... diagnosis #comparison #rheumatology
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