16 results
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Abnormal PT and/or aPTT ... typically prolong aPTT ... may prolong the aPTT ... Decreased factor ... Factor consumption
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Prolonged PT and aPTT ... the PT and the aPTT ... , FVII, FIX, FX ... , FVII, FIX, FX) ... #Abnormal #PT #aPTT
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... PT - Prolonged aPTT ... PT - Prolonged aPTT ... DrEricStrong #Algorithm ... Hematology #Diagnosis #Workup
Algorithm for managing FVII deficiency.

*Mild bleeding history includes minor epistaxis, menorrhagia, gastrointestinal bleeding, joint and soft
Algorithm for managing ... FVII deficiency ... #FVII #deficiency ... #FactorVII #Factor7 ... #Algorithm #management
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT)

Prothrombin Time (PT) - Often Elevated in:
 • Vitamin
Thromboplastin Time (PTT ... (warfarin) • Factor ... VII deficiency ... Heparinized line • Factor ... test tubes • Factor
Chest Pain - Diagnosis and Workup Algorithm

History and Exam
Acute life-threatening causes:
 • Acute myocardial infarction
 •
Diagnosis and Workup ... Algorithm History ... LET, lipase, PT. aPTT ... Pain #Diagnosis #Algorithm ... #workup
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
Differential Diagnosis Algorithm ... /uL Initial Workup ... iron studies, PT/aPTT ... Differential #Diagnosis #Algorithm ... #hematology #workup
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
NORMAL PT/NORMAL PTT ... Perform a PTT mixing ... VII should be undertaken ... VII deficiency ... the PT and the PTT
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... Reduced levels of factors ... VII, X, V and II ... Exposure → Tissue factor ... INR < 2.3 - APTT
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
not a major risk actor ... - No other workup ... screening, CBC, aPTT ... Hypercoagulable #Workup ... hematology #diagnosis #algorithm