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diagnosis hematology treatment differential coagulation medications pharmacology summary syndrome thrombocytopenia aflp anticoagulation clinical hellp hemeonc hemophagocytic hemostasis heparin hlh lymphohistiocytosis
Hemostasis Physiology The blood's response to blood vessel injury can be viewed as four interrelated steps. Roman
to coagulation factors ... PF-3, platelet factor ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
the Coagulation Cascade ... Initiation phase caused ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Summary table of ... Warfarin - Selective factor ... Direct thrombin (factor ... medications #doac #comparison ... #table #management
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
patientsl • Risk factors ... without other cause ... patients • Risk factors ... #diagnosis #comparison ... #table
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... generated by Tissue Factor ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Summary of Coagulation Deficiencies Inherited: • Hemophilia A - Deficiency of Factor VIII • Hemophilia B -
Deficiency of Factor ... Deficiency of Factor ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... normal in mild cases ... Chronic Management ... Hemophilia #Diagnosis #Management ... #treatment #hematology
Blood Product Components, Contents, Volume and Shelf Life Whole blood (autologous or directed donations) - RBC and
Factors V and VIII ... all coagulation factors ... von Willebrand factor ... Contents #Volume #Hematology ... #Management #Table
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential
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