39 results
Hemostasis Physiology

The blood's response to blood vessel injury can be viewed as four interrelated steps. 
Roman
to coagulation factors ... PF-3, platelet factor ... #Hemostasis #Pathophysiology ... #Coagulation #Cascade ... #Hematology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
the Coagulation Cascade ... Initiation phase caused ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Summary table of ... Warfarin - Selective factor ... Direct thrombin (factor ... medications #doac #comparison ... #table #management
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
patientsl • Risk factors ... without other cause ... patients • Risk factors ... #diagnosis #comparison ... #table
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation cascade ... generated by Tissue Factor ... #Coagulation #Cascade ... diagnosis #models #hematology ... #pathophysiology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Deficiency of Factor ... Deficiency of Factor ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Hemophilia - Diagnosis and Management
Diagnosis:
 • Consistent bleeding history (unless screening for disease in family members
Diagnosis and Management ... normal in mild cases ... Chronic Management ... Hemophilia #Diagnosis #Management ... #treatment #hematology
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
Factors V and VIII ... all coagulation factors ... von Willebrand factor ... Contents #Volume #Hematology ... #Management #Table
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... coagulation and other causes ... Venous #Arterial #pathophysiology ... #hematology #differential