7 results
Algorithm for Investigation of Abnormal Coagulation Tests
- Prolonged PT
- Prolonged aPTT and Prolonged PT
- Prolonged aPTT

Dr.
Algorithm for Investigation ... PT - Prolonged aPTT ... DrEricStrong #Algorithm ... #Laboratory #Hematology ... #Diagnosis #Workup
Mixing Study
 • Clotting tests can be abnormal due to either a clotting factor deficiency, or
either a clotting factor ... PT and/or aPTT) ... Study #diagnosis #hematology ... #pathophysiology ... #hematology #laboratory
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... protein C and S Pathophysiology ... venipuncture sites Laboratory ... INR < 2.3 - APTT ... treatment #management #hematology
Approach to the Hypercoagulable State
Arterial thromboembolism
→ Cardiac rhythm monitoring, Echocardiogram, Vascular imaging
→ Test for APS, particularly
not a major risk actor ... - No other workup ... screening, CBC, aPTT ... Hypercoagulable #Workup ... #algorithm #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
patientsl • Risk factors ... patients • Risk factors ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... von Willebrand factor-cleaving ... performed PT, PTT ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
Drug Induced Lupus vs SLE
Drug Induced Lupus (DIL):
 • Epidemiology: -10% of all lupus cases, drug-dependent,
calcium-b) • Laboratory ... • Immunologic Workup ... • Immunologic Workup ... druginduced #lupus #sle #comparison ... #table #rheumatology