9 results
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... Contemporary Model ... , resulting in coagulation ... EricsMedicalLectures/ #Coagulation ... #hematology #pathophysiology
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... EricsMedicalLectures/ #Coagulation ... Deficiencies #Summary #table ... #comparison #diagnosis ... #hematology #deficiency
Summary table of the mechanism of action, side effect and contraindications of commonly used anti-coagulation drugs.
Summary table of ... commonly used anti-coagulation ... Direct thrombin (factor ... medications #doac #comparison ... #table #management
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... Reduced levels of factors ... protein C and S Pathophysiology ... causes #treatment #management ... #hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... generated by Tissue Factor ... #Coagulation #Cascade ... PTT #diagnosis #models ... #hematology #pathophysiology
Blood Product Components, Contents, Volume and Shelf Life

Whole blood (autologous or directed donations) - RBC and
Factors V and VIII ... proteins, all coagulation ... factors, complement ... Contents #Volume #Hematology ... #Management #Table
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
hemorrhage, while under-coagulation ... #management #algorithm ... #medications #table ... decisionaid #cardiology #hematology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
patientsl • Risk factors ... patients • Risk factors ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
cells in the lymph nodes ... cell lymphoma Pathophysiology ... endothelial growth factor ... TAFRO #diagnosis #management ... #rheumatology #