22 results
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
Consumption of Clotting Factors ... protein C and S Pathophysiology ... Treat primary cause ... - APTT < 1.5 x normal ... #diagnosis #causes
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... intravascular coagulation ... Jcortesizaguirr #Abnormal ... aPTT #Prolonged #Causes
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Destruction • Abnormal ... Congenital • Factor ... Deficiency • Factor ... Diagnosis #Algorithm #Causes
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... amyloidosis #Abnormal ... aPTT #Prolonged #Causes ... differential #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework

== Quantitative or Qualitative defect in
inhibitor of a coagulation ... factor == NORMAL ... PT/ABNORMAL PTT ... intravascular coagulation ... discern these causes
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Acquired Risk Factors ... Thrombophilia: - Factor ... intravascular coagulation ... and other causes ... Venous #Arterial #pathophysiology
Review of the Coagulation Cascade
Traditional Model:
 • Parallel extrinsic and intrinsic pathways.
Contemporary Model:
 • 4 key
Review of the Coagulation ... Initiation phase caused ... , resulting in coagulation ... EricsMedicalLectures/ #Coagulation ... models #hematology #pathophysiology
Causes of Petechial Rash - Differential Diagnosis Algorithm

Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Thrombocytopenia - Abnormal ... deficiency - Abnormal ... Complete blood count coagulation ... Diagnosis #Algorithm #Causes
Lactated Ringers (LR) vs Normal Saline (NS) - Comparison

Composition of LR:
 • Sodium 130 mEq/L
 •
Saline (NS) - Comparison ... shift • Saline Causes ... • Saline May Cause ... Dilutes clotting factors ... - impair coagulation
NSAID vs ACEI/ARB effects on the Kidneys

Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
NSAIDs cause vasoconstriction ... patients with normal ... use shouldn't cause ... additional risk factors ... Nephrology #Renal #Pathophysiology