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diagnosis symptoms complications syndrome anorexianervosa diabetes diabeticketoacidosis disease dka erythematosus feedbackloop gauchers genetics gh glucocorticoids growthhormone hyperparathyroidism ileal lupus msk
Osteoporosis: Pathogenesis and risk factors • Age > 30 (post-peak bone mass) • Post-menopausal women ->
Osteoporosis: Pathogenesis ... 30 (post-peak bone ... Decr estrogen • Bone ... #pathophysiology ... #signs #symptoms
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Symptoms: Commonly no signs ... Fragile bones/osteoporosis ... easily/weakness, Bone ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Glucocorticoid-Induced Osteoporosis: Pathogenesis and Clinical Findings • Negative feedback on hypothalamus/pituitary, Decreasing ACTH -> Decr Sex
Glucocorticoid-Induced Osteoporosis ... -> Reduced Bone ... Formation, Increased Bone ... #pathophysiology ... #signs #symptoms
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease Pathophsiology ... Osteonecrosis, bone ... infarcts, osteoporosis ... Disease #Diagnosis #Signs
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Weakness, Incr CK • Bone ... Normal CK • Osteoporosis ... Complications #pathophysiology ... #signs #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome Signs ... Infertility • Decr Bone ... mineral density and osteoporosis ... Syndrome #genetics #pathophysiology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Incr IGF1 • Bone ... activates lipolysis Signs ... #FeedbackLoop #endocrinology ... #pathophysiology
Short Bowel Syndrome - Acute and Chronic Adverse Signs and Symptoms of Ileal Resection • Dehydration
Chronic Adverse Signs ... Nephropathy • Bone ... Disease, Osteoporosis ... ShortBowel #Syndrome #Signs ... Ileal #Resection #pathophysiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Note: in DKA, body ... brain... thus, the body ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
Anorexia Nervosa: Complications CARDIAC ABNORMALITIES - Functional: Low BP, Sinus bradycardia, prolonged QT interval - Structural: Reduced
- Osteopenia/Osteoporosis ... - Low bone mineral ... Emaciation: loss of body ... Complications #pathophysiology ... #diagnosis #signs
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