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diagnosis hematology differential oncology lymphocytic thrombocytosis basophilia basophils blood endocrinology globulin gout hemeonc hyperuricemia increased management markers mds mentzerindex mouth
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Chronic leukemia ... activity • ↓ LAP ... AML: Blast crises ... - infiltrates (anemia ... #Hematology #Oncology
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
- CD7, CD3 Chronic ... Pelger-Huet, Macrocytic anemia ... • Lymphoid (CLL ... or λ), Smudge Cells ... #hematology #Markers
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... • Chronic myelogenous ... vera Acute Leukemia ... pancytopenia, blast cells ... #Causes #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... lymphoproliferative disorders ... • Neutropenia, anemia ... #Chronic #Lymphocytic ... workup #oncology #hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Differential Diagnosis Algorithm ... Lymphoproliferative Disorders ... (AML) • Chronic ... Anemia - Others ... endocrinology #causes
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia ... • Rheumatic disorders ... Iron deficiency anemia ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... inflammatory disorders ... myeloid leukemia ... (CML) - Dr.
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
similarly to mast cells ... Myeloproliferative Disorders ... : • Chronic myeloid ... leukemia (CML) ... #hematology #basophils
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic ... Leukemia (CLL) ... in adults • Disorder ... lymphocytes, smudge cells ... 5) Symptoms of anemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... caused by blood ... Marrow Failure • Chronic ... Myelogenous Leukemia ... Leukemia • Idiopathic
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