407 results
diagnosis differential causes algorithm hematology pathophysiology management endocrinology clinical anemia nephrology signs symptoms treatment iron neurology workup nutrition disease physicalexam
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH ... dysfunction, ↑ Ferritin ... • Familial HLH ... XLP) Acquired HLH ... Cellular immune deficiency
Hemophagocytic Lymphohistiocytosis (HLH) Clinical Features: Fever, Splenomegaly, Hepatomegaly, Lymphadenopathy, Confusion Classic lab findings in HLH: ↑↑ ferritin, Anemia,
Lymphohistiocytosis (HLH ... lab findings in HLH ... : ↑↑ ferritin, Anemia ... consistent with HLH ... cell lines) • ↑ ferritin
Diagnostic Schema for Hyperferritinemia Pearl: Diseases associated with extreme elevations: 1. HLH 2. Still's disease 3. Systemic
HLH 2. ... histoplasmosis #Ferritin
Iron Panel Interpretation Iron deficiency - ↓ Iron, ↑-nl Transferrin / TIBC, ↓ Transferrin Saturation, ↓
Interpretation Iron deficiency ... Saturation, ↓ Ferritin ... Saturation, ↑-nl Ferritin ... Iron deficiency ... Interpretation #deficiency
Causes of Hyperferritinemia - Differential Diagnosis Ferritin > 1000 Ferritin is the storage form of iron. Increased hepcidin
Differential Diagnosis Ferritin ... > 1000 Ferritin ... hepcidin prevents ferritin ... HLH or Adult Onset ... In adults, HLH is
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Iron Deficiency ... Algorithm Labs: Ferritin ... Zinc excess or deficiency ... , Copper deficiency ... Diagnosis #Algorithm #ferritin
Iron Deficiency in Heart Failure - Diagnosis and Treatment Algorithm Diagnosis: Ferritin <100 ng/mL (absolute ID) OR
Iron Deficiency ... Algorithm Diagnosis: Ferritin ... absolute ID) OR Ferritin ... Ill HF with iron deficiency ... HFrEF and iron deficiency
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Diseases: • GATA2 deficiency ... erythematosus • HLH ... B12 • Folate deficiency
Iron Deficiency Anemia (IDA) Tests: • MCV/RBC - RBC ↓ in proportion to the ↓ in hemoglobin
Iron Deficiency ... synthesis • Ferritin ... DharSaty #Iron #Deficiency ... #Anemia #IDA #ferritin
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Lymphohistiocytosis (HLH ... / Diagnosis: HLH ... cell activity • Ferritin ... If no response HLH ... TheIDtrivia #HLH
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