22 results
Warm vs Cold Autoimmune Hemolytic Anemia
Warm Autoimmune Hemolytic Anemia:
 • Mechanism: IgG and Complement-mediated
 • Etiology:
Warm vs Cold Autoimmune ... Hemolytic Anemia ... Immunosuppression, Splenectomy Cold ... BostonChiefs #Warm #Cold ... #Anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... Autoimmune (AIHA)"Cold ... (e.g. primary cold ... differential #diagnosis #hematology ... #anemia
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
Intravascular Hemolysis ... Warm AIHA • Cold ... Complement-Mediated • Cold ... anemia • ... Algorithm #Causes #Hematology
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic ... Anemia (AIHA) - ... #Autoimmune #Hemolytic ... #Anemia #AIHA # ... Diagnosis #Table #hematology
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... - Warm vs Cold ... Smear: spherocytes Cold ... #diagnosis #hematology
Vasculitis: In this instance, the vasculitic skin lesions were secondary to Haemophilus endocarditis.
Photo credit, Josh Fierer,
to Haemophilus endocarditis ... Photo credit, Josh Fierer ... Clinical #Photo #Dermatology ... #SkinRash #Vasculitis ... #Endocarditis #
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
nose, ears, or fingers ... • Symptoms of anemia ... Diagnosis: • hemolytic ... anemiaCold ... #anemia #hematology
Osler's Nodes: Painful, erythematous nodules associated with bacterial endocarditis. 
Photo credit, Josh Fierer, M.D.

Charlie Goldberg, M.D.
with bacterial endocarditis ... Photo credit, Josh Fierer ... Clinical #Photo #Dermatology ... #SkinRash #OslersNodes
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic ... Anemia (AIHA) Treatment ... azathioprine Cold ... #Anemia #AIHA # ... Treatment #management #hematology
Janeway Lesions: Flat, painless, erythematous lesions seen on the palm of this patient's hand. Frequently
associated with
with bacterial endocarditis ... Photo credit, Josh Fierer ... Clinical #Photo #Dermatology ... #SkinRash #Janeway ... #Lesions #Endocarditis