73 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Abnormal peripheral smear ... Anemias (AIHAs) ... Anemias (AHAs) ... Diagnosis #Algorithm #hematology
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Anemia Intravascular ... LDH Peripheral smear ... #Anemia #Laboratory ... workup #diagnosis #hematology ... #hemolysis
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Peripheral Blood ... Smear Analysis ... #Smear #Analysis ... #hematology #microscopy ... interpretation #clinical
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... AIHA • Anemia ... type ± C3d • Blood ... smear: Differential
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... • Peripheral blood ... smear + DAT + further ... → Sickle Cell anemia ... anemia (TTP, HUS
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... DIC is a clinical ... arrow) Peripheral smear ... #anemia #Hematology ... #Pathology #Smear
Autoimmune Hemolytic Anemia (AIHA) Pathophysiology - Warm vs Cold AIHA
Warm AIHA:
 - 70%; IgG mediated
 -
Autoimmune Hemolytic ... Anemia (AIHA) Pathophysiology ... or negative - Smear ... C3 positive - Smear ... #diagnosis #hematology
Dacrocytes (tear drop cells) 
Other poikilocytes resemble a pear or teardrop. The narrow, tapered end
may be
thalassemia, and some hemolytic ... anemias. ... #Clinical #Path ... #BloodSmear #Blood ... #Smear #Dacrocytes
Gonorrhea (Disseminated): skin findings associated with Disseminated Gonococcal Infection (DGI).
Photo credit, Josh Fierer, M.D.

Charlie Goldberg, M.D.
Photo credit, Josh Fierer ... UCSD Catalog of Clinical ... Images #Clinical ... #Dermatology #SkinRash ... #Disseminated #Finger
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
smear showed numerous ... , a form of hemolytic ... inflexible and prone to hemolysis ... #NEJM #clinical ... #smear