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management hematology algorithm hemolytic neurology agglutinin antibody autoimmune classification cold disease encephalopathy framework gravis hemodialysis hodgkins hyperkalemia hyperphosphatemia k lymphoma
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Anemia 1) DIAGNOSE ... • IgG type ± C3d ... • Blood smear: Differential ... #Anemia #diagnosis ... #management #treatment
Workup for Hyperphosphatemia - Differential Diagnosis Framework Rule out spurious hyperphosphatemia: paraproteinemia, hyperlipidemia, hemolysis, hyperbilirubinemia, liposomal amphotericin
Workup for Hyperphosphatemia ... - Differential ... Diagnosis Framework ... Disease: • AKI, CKD ... #nephrology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
nose, ears, or fingers ... • Symptoms of anemia ... Diagnosis: • hemolytic ... anemia • Cold ... younger pts) Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Diagnosis Algorithm ... hematology for workup ... blood loss, Acute hemolysis ... , deficiency anemia ... Rebound effect from treatment
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoantibodies: • WAIHA • CAD ... • Coombs (-) hemolytic ... anemia due to cold ... Hematology #Monoclonal #Differential ... #Diagnosis #Oncology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
injury, ischemia, hemolysis ... reabsorption) Workup ... Pseudohyperkalemia - hemolysis ... VBG (acidosis), CK ... #potassium #nephrology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
life-threatening Differential ... myasthenia Diagnosis ... immunosuppressants - Meds ... Myasthenia #Gravis #diagnosis ... #management #neurology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... Hodgkin Lymphoma Treatment ... classification #hematology #oncology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Workup: • Complete ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
by 24 hours or longer ... Reversible course Differential ... epilepticus Treatment ... underlying cause • Treatment ... #management #neurology
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