Finger photo diagnosis dermatology syndrome rheumatology algorithm monoclonal hemolytic mgus

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Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,

Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
(+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia

Significance (MGUS ... - Differential Diagnosis ... capillary leak syndrome ... #Significance #MGUS ... #hematology #oncology

Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined

Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone

Can Feature A Monoclonal ... • MM • WM • MGUS ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Diagnosis #Oncology

Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
1. Cold Agglutinins (CAD)
2. Donath-Landsteiner

Cold Agglutinin Syndrome ... nose, ears, or fingers ... Diagnosis: • hemolytic ... significance (MGUS ... #anemia #hematology

Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film.
TTP/HUS indicates thrombotic

Algorithm for workup ... thrombocytopenic purpura/hemolytic ... uremic syndrome ... thrombocytopenia, Hematology ... 2012, p 193 #Diagnosis

Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R

Multiple Myeloma and Monoclonal ... if this is is monoclonal ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology

Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?

- Differential Diagnosis ... → Refer to hematology ... blood loss, Acute hemolysis ... Kawasaki, Nephrotic syndrome ... #Algorithm #hematology

Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

• Blood loss:

- Differential Diagnosis ... Algorithm Labs ... extravascular) hemolysis ... Gastrectomy, WHDA syndrome ... #hematology

Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•

Gammopathy Include: • MGUS ... changes (POEMS syndrome ... gastric tumors • Hematology ... #differential #diagnosis ... #hematology

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