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diagnosis differential algorithm hematology iron b12 cobalamin thrombocytosis vitamin cardiology extremity ferritin gastroenterology leg lower management msk pain pathophysiology physicalexam
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Loss (without anaemia ... Bleeding, Edema, Celiac ... Disease (IBD, cancer ... #nutrition
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... Inflammation: IBD ... , Chronic disease ... #nutrition
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Intestine: SIBO, Celiac ... disease, IBD, Lymphoma ... Stomach: Pernicious anemia
Suspected Celiac Disease - Diagnosis Algorithm Celiac disease suspected: • Signs and symptoms of celiac disease •
Suspected Celiac ... disease • Iron-deficiency ... anemia unresponsive ... without discernable cause ... Inflammatory (IBD
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Inflammatory: • IBD ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... - Structural: Celiac ... disease, Tropical ... sprue, IBD, Bypass ... surgery, Bacterial
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... papillae of tongue), abd ... diarrhea related to IBD ... , celiac disease ... diagnosis #management #nutrition
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Acute hemolysis, deficiency ... anemia, Rebound ... Vasculitides, IBD ... , Celiac disease ... infections, TB, Acute bacterial
Widened Pulse Pressure - Differential Diagnosis and Pathophysiology Pulse pressure is the difference between the systolic blood
Stroke Volume / Arterial ... less compliant arteries ... • Severe iron deficiency ... anemia (reduced ... Arteriovenous fistula
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Legg-Calve-Perthes disease ... • Bursitis • IBD ... ulcers, Edema Arterial ... Vit B12, B6, Cu deficiency ... lower #extremity #msk
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