31 results
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
disease anemia ... Microangiopathic Hemolytic ... Cold autoimmune hemolytic ... #Morphology #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... #Anemia #Differential ... Diagnosis #Algorithm #workup ... #hematology #testing
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Volume (MCV) - Differential ... Bleed • Hemolysis ... • Early Iron Deficiency ... #Differential # ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas
 • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell (RBC ... spherocytosis, Hemolytic ... Schistocytes - Hemolytic ... key #diagnosis #differential ... #hematology
Common RBC Inclusions and Associations
 • Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
 • Heinz
Common RBC Inclusions ... Bodies: G6PD deficiency ... , Hemolytic anemia ... : Hemoglobin H disease ... Bodies #diagnosis #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... Reticulocytes • Iron Deficiency ... • B12/Folate Deficiency ... Disease • Marrow ... Algorithm #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... • Intrinsic RBC ... G6PD deficiency) ... Extravascular #Causes #differential ... #anemia
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
- Differential ... , CKD • Hemolytic ... Spherocytosis, G6PD, PK, HbC ... Non-megaloblastic: Liver disease ... #Diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... DAT (-) → G6PD Deficiency ... Hypochromic & microcytic RBCs ... malignancy, autoimmune disease ... #Anemia #Differential
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
- Differential ... elliptocytosis - RBC ... • PK deficiency ... anemia • ... Algorithm #Causes #Hematology