16 results
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
RBC casts in urine ... Proteinuria often ... but in severe cases ... Nephrotic #Syndromes #Classification ... #Proteinuria #Nephrology
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
(Negative urine ... (Positive urine ... albuminuria) - Active urine ... sediment - WBC/RBC casts ... #Nephrology #Differential
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
hematuria and/or proteinuria ... hematuria (RBC casts ... dysmorphic RBCs in urine ... Comparison #Algorithm #Nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
WBCs, or urine ... glomerular bleeding (proteinuria ... , RBC casts, dysmorphic ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology
Albuminuria (Grades) and Risk for CKD
Normal to mildly increased albuminuria:
 - Albumin excretion rate: < 30
Nephrotic-range proteinuria ... : - Urine total ... Albuminuria #Grades #classification ... #CKD #nephrology ... #diagnosis #proteinuria
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
proteins, documenting proteinuria ... • Urinary casts ... [(U Na x P Cr) / ... (P Na x U Cr)] ... #UNa #casts #glucosuria
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
overt glomerular proteinuria ... arbitrarily defined as urine ... cell/white cell casts ... because nephritic urine ... nephrotic #syndrome #nephrology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN
 • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
GN • Active Urine ... dysmorphic RBC, RBC casts ... , +/- proteinuria ... Glomerulonephritis #MPGN #nephrology
Hypertensive Disorders of Pregnancy
Chronic Hypertension:
 • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg
 •
, 300 mg/24 hr urine ... ratio ≥ 0.3, or Urine ... insufficiency (Cr ... or doubling of Cr ... htn #obstetrics #cardiology
Hepatorenal Syndrome Diagnosis
 • ↑ in serum Cr of ≥ 0.3mg/dL above baseline
• ↑ in serum Cr ... (including no proteinuria ... ) • ↓ urine output ... 2 HRS) • Low urine ... diagnosis #HRS #nephrology