23 results
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
the patient has hematuria ... and/or proteinuria ... (RBC casts or dysmorphic ... RBCs in urine)? ... Comparison #Algorithm #Nephrology
Hematuria Workup and Diagnosis Algorithm
 • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
Hematuria Workup ... glomerular bleeding (proteinuria ... , RBC casts, dysmorphic ... → Refer to Nephrology ... cystoscopy • Refer to Nephrology
Glomerular Diseases - Nephritic and Nephrotic Syndromes

Nephritic syndrome—due to GBM disruption. 
Hypertension. t BUN and creatinine.
hematuria. ... RBC casts in urine ... Proteinuria often ... but in severe cases ... #Nephrology #Diagnosis
Differentiation Between Nephrotic Syndrome and Nephritic Syndrome 
== Nephrotic Syndrome ==
Onset - Insidious 
Edema - ++++
Blood
- Normal/low Proteinuria ... - ++++ Hematuria ... Red blood cell casts ... - ++ Hematuria ... Red blood cell casts
Causes of Proteinuria - Differential Diagnosis Algorithm
Persistent Proteinuria >150mg/d protein present on repeat testing including overnight
(Negative urine ... (Positive urine ... albuminuria) - Active urine ... sediment - WBC/RBC casts ... #Nephrology #Differential
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
: Red/Dark urine ... 1ml blood/liter urine ... : - RBC casts ... - Proteinuria ... causes #urology #nephrology
Algorithmic Approach to Acute Interstitial Nephritis
When to suspect AIN? (not sensitive)
 • AKI, AKD, rapidly progressive
sterile pyuria, WBC casts ... eosinophiluria, microscopic hematuria ... , mild tubular proteinuria ... , granular casts ... AIN #Algorithm #nephrology
Urinalysis & Urine Sodium 
Theophilus Protospatharius, a seventh-century physician who wrote the first manuscript focused exclusively
proteins, documenting proteinuria ... • Urinary casts ... [(U Na x P Cr) / ... #UNa #casts #glucosuria ... #hematuria
Causes of Hematuria - Differential Diagnosis Algorithm
Red blood cells on urine microscopy. Must exclude false positives
Causes of Hematuria ... blood cells on urine ... RBCs and/or RBC casts ... ) - Isolated Hematuria ... nephrotic range) proteinuria
Algorithm - Approach to the differential diagnosis of the patient presenting with overt glomerular proteinuria. CMV
arbitrarily defined as urine ... cell/white cell casts ... because nephritic urine ... Hematuria may be ... nephrotic #syndrome #nephrology