70 results
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Syndrome (MD) - Diagnosis ... old, ~10,000 new cases ... only curative treatment ... #Management #treatment ... #hematology #oncology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... randomized controlled trial ... thrombosis; PE = pulmonary ... Anticoagulation #Management #Hematology ... #Oncology
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients)
Important notes:
 • No
calculators - HAS-BLED (atrial ... validated for VTE treatment ... studies suggest net clinical ... Anticoagulation #Factors #Hematology ... #Diagnosis
Autoimmune Myositis
Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
heliotrope rash, Shaw sign ... , holster sign, ... at diagnosis). ... after 2 years of treatment ... #rheumatology
Portopulmonary Hypertension
Presence of pulmonary arterial hypertension in a patient with portal hypertension
No other obvious causes (chronic
other obvious causes ... m/s • Other signs ... ventricular size, Right atrial ... pressure < 15mmHg TREATMENT ... - Mechanism: causes
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
for secondary causes ... glucocorticoid treatment ... organ-specific signs ... #Differential #diagnosis ... #hematology #eosinophilia
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Still's Disease Clinical ... triad: Fever, Arthralgia ... hepatitis • Pulmonary ... #management #treatment ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
treatment Pathophysiology ... Imaging: CXR- pulmonary ... Renal Failure Treatment ... #management #hematology ... #oncology
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
skin thickening Signs ... calcinosis • Pulmonary ... arterial HTN) ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Hyperthyroidism Overview

Clinical Manifestation of Hyperthyroidism:
 • Fatigue
 • Weight loss
 • Heat intolerance
 • Depression, nervousness
Hyperthyroidism Overview Clinical ... Ophthalmoplegia • Atrial ... fibrillation/flutter ... hyperthyroidism #causes ... endocrinology #signs