27 results
diagnosis hematology oncology causes thrombocytosis algorithm classification infectiousdiseases leukemia cardiology cll endocarditis lymphocytic platelets vasculitis abscess activation allergy aplastic arteritis
Thrombocytosis - Differential Diagnosis Platelet Count > 450 Reactive: • Anemia/blood loss (Fe deficiency) • Infection/Sepsis • Non-infectious
Thrombocytosis - Differential ... Reactive: • Anemia ... deficiency) • Infection ... Sepsis • Non-infectious ... Myelofibrosis • Chronic
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... Infection) High ... Classification #Differential ... Algorithm #Causes #Hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
hypogammaglobulinemia -> increased infection ... history of recurrent infections ... disease • Infectious ... community-acquired infections ... infections (Epstein-Barr
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
deficiencies: Chronic ... (e.g. cancer, infection ... G6PD deficiency), Infections ... Production #Index #hematology ... #anemia #differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Inflammatory Conditions: Rheumatologic ... TPO, TPO-RA • Infections ... : Chronic infections ... bacterial and viral infections
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... : • Acute or Chronic ... Iron deficiency anemia ... Algorithm #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Thrombocytosis): • Acute infection ... malignancies • Anemia ... hemorrhage) • Chronic ... Diagnosis #Causes #hematology
Important organisms in Chronic Granulomatous Disease (CGD): - Staph aureus - Serratia marcescens - Burkholderia cepacia
Important organisms in Chronic ... Granulomatous #Disease #infections ... #differential # ... ddx #diagnosis # ... microbiology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Neutropenia - recurrent infections ... Idiopathic • Infections ... and thymoma DDX ... #oncology #hematology ... #diagnosis #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Malaise, bleeding, infections ... pain, bleeding, infections ... bruising, bleeding, infection ... - infiltrates (anemia ... plaques) AML Dx
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