11 results
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Pathogenesis and clinical ... Signs/Symptoms ... Incr Skeletal fractures ... • Short stature ... , sleep apnea, cor
Ankylosing Spondylitis: Pathogenesis and Clinical findings
 • Pain in lumbar area and gluteal region: (Dull, insidious
Pathogenesis and Clinical ... more constant as disease ... bamboo spine) -> Fracture ... pathophysiology #diagnosis #signs ... #symptoms
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... Lower motor neuron symptoms ... Upper motor neuron symptoms ... anterior horn gray ... Vertebral burst fracture
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Paget’s Disease: ... Pathogenesis and Clinical ... , kyphosis and fractures ... pathophysiology #diagnosis #signs ... #symptoms
Characteristic clinical manifestations of Down syndrome 
 
Typical craniofacial appearance 
 • Round face and flat
Characteristic clinical ... manifestations of Down syndrome ... #Downs #Syndrome ... #PhysicalExam # ... Features #Signs
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
neurological lesion: Clinical ... and signs below ... compression by fractured ... Sarcoidosis, Behcet disease ... MCTD, Sjogren syndrome
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
Diagnosis and Clinical ... , pathological fractures ... /or MRI of the skull ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology
Multiple Sclerosis - Summary

Multiple Sclerosis (MS) is an autoimmune-mediated neurodegenerative disease of the central nervous system
neurodegenerative disease ... • Or brainstem syndromes ... Signs and symptoms ... stimulation Clinical ... Progressive MS (Spinal cord
Celiac Disease - Clinical Manifestations
Gastrointestinal Manifestations: 
 • Diarrhea, Loose stools, Dyspepsia, Flatulence, Chronic abdominal pain,
Celiac Disease - ... Clinical Manifestations ... ulceration • Short ... Osteoporosis, Bone fractures ... #signs #symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Paget’s Disease: ... -> Pathologic fractures ... or the spinal cord ... radiculopathy • Skull ... #symptoms #complications