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diagnosis pathophysiology erythematosus lupus rheumatology systemic algorithm ankylosingspondylitis celiac cord cushings differential disorders downs endocrinology features gastroenterology genetics hypercortisolism manifestations
Ankylosing Spondylitis: Pathogenesis and Clinical findings • Pain in lumbar area and gluteal region: (Dull, insidious
Pathogenesis and Clinical ... more constant as disease ... bamboo spine) -> Fracture ... pathophysiology #diagnosis #signs ... #symptoms
Prader-Willi Syndrome: Pathogenesis and clinical findings • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Prader-Willi Syndrome ... Pathogenesis and clinical ... Signs/Symptoms ... Incr Skeletal fractures ... • Short stature
Paget’s Disease: Pathogenesis and Clinical Findings • Incr serum CTx - marker of bone resorption •
Paget’s Disease: ... Pathogenesis and Clinical ... , kyphosis and fractures ... pathophysiology #diagnosis #signs ... #symptoms
Characteristic clinical manifestations of Down syndrome Typical craniofacial appearance • Round face and flat
Characteristic clinical ... • Brushfield spots ... iris (pigmented spots ... #PhysicalExam # ... Features #Signs
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Demyelinating syndromes ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
Diagnosis and Clinical ... , pathological fractures ... /or MRI of the skull ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... Clinical Features ... • Malar rash - spares ... Induced Lupus: • Symptoms ... SSA can rule in SLE
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
neurological lesion: Clinical ... and signs below ... compression by fractured ... - SLE, Scleroderma ... MCTD, Sjogren syndrome
Celiac Disease - Clinical Manifestations Gastrointestinal Manifestations: • Diarrhea, Loose stools, Dyspepsia, Flatulence, Chronic abdominal pain,
Celiac Disease - ... Clinical Manifestations ... ulceration • Short ... Osteoporosis, Bone fractures ... #signs #symptoms
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