9 results
Prader-Willi Syndrome: Pathogenesis and clinical findings
 • Maternal uniparental disomy: inheriting 2 copies of maternal chromosome
Signs/Symptoms ... Incr Skeletal fractures ... • Short stature ... , sleep apnea, cor ... #genetics #pathophysiology
Lesions of the Spinal cord - Spinal Cord Syndromes

Spinal cord lesions can result in permanent neurologic
- Spinal Cord Syndromes ... Lower motor neuron symptoms ... Upper motor neuron symptoms ... anterior horn gray ... Vertebral burst fracture
Fat Embolism Syndrome
Trauma to the long bone or pelvis accounts for —9096 of cases. The diagnosis
Fat Embolism Syndrome ... stabilization of fractures ... Pathophysiology ... FES is a clinical ... Diagnosis #Signs #Symptoms
Ankylosing Spondylitis: Pathogenesis and Clinical findings
 • Pain in lumbar area and gluteal region: (Dull, insidious
Pathogenesis and Clinical ... progresses) - X-ray ... bamboo spine) -> Fracture ... AnkylosingSpondylitis #pathophysiology ... diagnosis #signs #symptoms
Paget’s Disease: Pathogenesis and Clinical Findings

 • Incr serum CTx - marker of bone resorption
 •
Pathogenesis and Clinical ... Skull involvement ... , kyphosis and fractures ... PagetsDisease #pathophysiology ... diagnosis #signs #symptoms
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
neurological lesion: Clinical ... findings: • Symptoms ... compression by fractured ... MCTD, Sjogren syndrome ... Symptoms: • Back
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features
1) Skin
 • Thin, easily bruisable skin with
Cushing's Syndrome ... Diagnosis and Clinical ... , pathological fractures ... /or MRI of the skull ... Diagnosis #signs #symptoms
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
-> Pathologic fractures ... or the spinal cord ... radiculopathy • Skull ... PagetsDisease #pathophysiology ... diagnosis #signs #symptoms
Rickets and Osteomalacia: Pathogenesis and Clinical Findings
 • Calcification inhibitors (excess exposure to A1, Fluoride, etidronate)
Pathogenesis and Clinical ... closure => • Short ... Bowed legs • Fractures ... #Osteomalacia #pathophysiology ... diagnosis #signs #symptoms