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diagnosis differential hepatology lfts management transaminitis alkaline dermatology enzymes gastroenterology hematology nephrology phosphatase workup aafp abnormal acidosis acute aflp amyloid
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... vs bone Bili - Direct ... #FunctionTest # ... LFTs #Elevation
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Liver Chemistries ... Bilirubin - +/- elevation ... life: 1 week • Direct ... or amyloid: • Elevation ... Enzyme Elevation
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... Bilirubin - +/- elevation ... Half-life: 1 week • Direct ... Enzyme Elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Diagnosis Algorithm ... disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... #Diagnosis #Algorithm
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic Liver ... Hepatocellular Liver ... elevation > Alk
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Differential Diagnosis Algorithm ... Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... Differential Diagnosis Algorithm ... Severe ALT > 15x ... Differential #Diagnosis #Algorithm ... #Causes
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
tests algorithm ... box indicates all ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... LFTs #Abnormal #Algorithm
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... Pathophysiology: • Defect ... hepatocytes → Liver ... = nonspecific (nausea ... #Fatty #Liver #
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Differential Diagnosis Algorithm ... Iatrogenic) • Liver ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
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