15 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
(LFTs) Elevation ... Transaminase >> Alkaline ... Pattern - Alkaline ... #FunctionTest # ... LFTs #Elevation
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury
Hepatocellular Liver Injury
 • AST/ALT elevation
Hepatocellular and Cholestatic ... • AST/ALT elevation ... + ULN ALT) / (alkaline ... phosphatase + ULN alkaline ... R ≤ 2 = Cholestatic
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
Alkaline Phosphatase ... disturbance (obstructed liver ... Highest • Bone • Liver ... of Intrahepatic cholestasis ... - Pruritis - Cholestasis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
RNA • R < 2: Cholestasis ... Bilirubin - +/- elevation ... Obstruction: Cholestasis ... or amyloid: • Elevation ... Enzyme Elevation
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
poisoning, ETOH Cholestatic ... Bilirubin - +/- elevation ... Labs in Cholestatic ... epithelia: - Cholestasis ... Enzyme Elevation
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... Interpretation Alanine ... , lungs, RBCs Alkaline ... nucleotidase - Liver ... , intrahepatic cholestasis
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... compared with alkaline ... phosphatase) 2) Cholestatic ... disproportionate increase in alkaline
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... Tests - AST, ALT, Alkaline ... In liver, 80% of ... Alkaline phosphatase ... hepatocyte - Elevation
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... Intrahepatic Cholestasis ... to 10-20-fold elevation ... Histology: Normal-mild cholestasis ... to 10-20-fold elevation
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... derangement of liver ... magnitude of enzyme elevation ... ALP, alkaline phosphatase ... ; ALT, alanine aminotransferase