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diagnosis hepatology differential lfts algorithm transaminitis alkaline alp chemistry gastroenterology hepatitis hyperbilirubinemia infectiousdiseases laboratory phosphatase workup acidosis acute aflp alkphos
Liver Function Test (LFTs) Elevation AST - Cardiac and skeletal muscle, kidney, brain ALT - More specific for
Liver Function Test ... (LFTs) Elevation ... specific for the liver ... #FunctionTest # ... LFTs #Elevation
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Liver Chemistry ... Phosphatase and Bilirubin ... hepatocyte - Elevation ... initial insult Bilirubin ... ASTALT #AlkPhos #Bilirubin
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
to 10-20-fold elevation ... , Bilirubin: <5 ... to 10-20-fold elevation ... , Bilirubin: <5 ... but variable ++, Bilirubin
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
- +/- elevation ... week • Direct bilirubin ... or amyloid: • Elevation ... Enzyme Elevation ... : • Bilirubin:
Approach to Conjugated Hyperbilirubinemia - Differential Diagnosis Algorithm 1. Definition: T.bili elevation + >20% conjugated 2. Obtain RUQ
Definition: T.bili elevation ... non-ICU vs ICU causes ... MRCP, ERCP, liver ... Hyperbilirubinemia #direct #bilirubin
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... - +/- elevation ... week • Direct bilirubin ... Enzyme Elevation ... : • Bilirubin:
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... ) - Causes of Hepatocellular ... and Cholestatic Liver ... Hepatocellular Liver ... Injury • AST/ALT elevation
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Phosphatase (ALP) Elevation ... disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... of elevation:
Commonly Observed Laboratory Findings in Hepatic / Liver Failure - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... and unconjugated bilirubin ... and excretion of bilirubin ... ALT and AST - Elevations ... fold with acute liver
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
function: INR, bilirubin ... Post-Hepatic: • Cardiac causes ... sarcoidosis) • Liver ... metastasis • Fatty liver ... Differential #Diagnosis #causes
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