7 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... abnormality vs bone Bili ... ALP ≥ 2x ULN R Value ... Hepatocellular injury ... #FunctionTest #
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Injury (DILI) ... dose dependent injury ... Calculate R-Value ... #differential # ... gastroenterology #algorithm
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
Elevated Liver Function ... Tests (LFTs) - Differential ... (>1000): • DILI ... injury) • Ischemic ... #Function #Tests
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... - Differential ... Diagnosis Algorithm ... • Iatrogenic: DILI ... Tests of synthetic function
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Liver Function Tests ... LFTs) - Normal Values ... bilirubin (Conjugated/DBili ... hepatocellular injury ... #Function #Tests
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs R-value ... injury < 26 weeks ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
Shock - Differential ... Insufficiency, Liver ... Medications, Spinal Cord Injury ... Decompensated CHF, Severe Valve ... #criticalcare #algorithm