11 results
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... specific for the liver ... SinaiBmoreIMRes #Liver ... #FunctionTest #
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
• Infectious: Hepatitis ... NAFLD, Autoimmune hepatitis ... biliary obstruction, HELLP ... Pregnancy, Alcoholic Hepatitis ... Sepsis, Viral Hepatitis
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Liver Disease in ... , no necrosis HELLP ... hepatology #obstetrics #hepatitis ... #comparison #differential ... diagnosis #icp #HELLP
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
• Congenital: HELLP ... Trauma: Shock liver ... • Autoimmune hepatitis ... Transaminases #hepatitis
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Pregnancy - TTP/HUS, HELLP ... and Acute Fatty Liver ... coagulation defects. 1) HELLP ... Thrombocytopenia #TTPHUS #HELLP ... diagnosis #table #comparison
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
Hepatocellular Liver ... Injury → liver ... • Infections: Hepatitis ... NAFLD, Autoimmune, HELLP ... Transaminitis #LFTs #hepatitis
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
coagulation defects. 1) HELLP ... Hemolysis, Elevated Liver ... exchange 2) Fatty liver ... Pregnancy #TTPHUS #HELLP ... Hematology #Diagnosis #Comparison
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Autoimmune: Autoimmune hepatitis ... • Pregnancy: HELLP ... Chronic viral hepatitis ... #injury #hepatitis
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Pregnancy - AFLP, HELLP ... • Alcoholic hepatitis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
Acute Fatty Liver ... hepatocytes → Liver ... malaise) → Acute liver ... Diagnosis: Viral Hepatitis ... Preeclampsia, HELLP