29 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
urearetics) 3) Loop ... agents (eg, furosemide ... Sites #Action #nephrology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
mannitol) 3) Loop ... Diuretics (e.g. furosemide ... Pathophysiology #Nephrology
Diuretics sites of action on the nephron
1) Acetazolamide (carbonic anhydrase inhibitor)
2) Osmotic diuretics (e.g. mannitol)
3) Loop
. mannitol) 3) Loop ... diuretic (e.g. furosemide ... #pharmacology #nephrology
Summary of Diuretic Agents 
Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction
CARBONIC ANHYDRASE
empagliflozin LOOP ... DIURETICS • Furosemide ... summary #table #nephrology
Flowchart to diuretic use in acute heart failure.

(A) Congestion with volume overload. 

(B) Treatment algorithm after
(B) Treatment algorithm ... Total loop diuretic ... generally considered furosemide ... following a single loop ... Diuresis #CHF #Algorithm
Drugs associated with hypokalemia and hypomagnesemia

Hypokalemia
- Shift from extracellular fluid to intracellular fluid compartment
  -
Acetazolamide - Furosemide ... and other loop ... Diuretics - Furosemide ... differential #diagnosis #nephrology
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... • Bumetanide, Furosemide ... #Pharmacology #nephrology ... #conversion #loop
Hypokalemia - Differential Diagnosis Algorithm
Extra-renal Losses:
 • Normal Acid-Base: Low intake
 • Metabolic acidosis: Gl tract
Differential Diagnosis Algorithm ... • HTN Absent: Loop ... Differential #Diagnosis #Algorithm ... potassium #low #nephrology
Hyponatremia Correction
1. Indications for Hypertonic Saline: seizure, coma, focal findings
   - typically occurs with
water @ 3cc/kg/h, loop ... MH/CCF/CWRU EM ... rate #management #nephrology
Management of status epilepticus

Big thanks to Dr. Grossman, one of MetroHealth's neurocritical care attendings for his
- MH/CCF/CWRU EM ... Management #Seizure #Algorithm ... #CriticalCare #Neurology