69 results
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
Growth Hormone (GH ... : • Liver -> GHR ... • Muscle -> GHR ... /Symptoms: • GH ... endocrinology #pathophysiology
Primary sclerosing cholangitis (PSC) - Malignancy Screening and Surveillance Recommendations 

Cholangiocarcinoma 
 - Annual US or
MRCP & CA 19-9 Gallbladder ... recommended for any GB
Gallbladder Perforation with pericholecystic abscess on POCUS

Patient with RUQ pain/fever.  Answer in thread. holecystitis/impacted stone
Gallbladder Perforation ... stone in neck with GB ... perforation and GB ... Cholecystitis #Gallbladder
Growth Hormone Excess - Pathogenesis and clinical findings
 • Acromegaly and gigantism share the same pathophysiology
share the same pathophysiology ... time of onset of GH ... GH excess prior ... GH excess after ... endocrinology #pathophysiology
Antibiotic Stewardship: Shorter is Better
CAP 3-5d = 5-14d
VAP 8d = 15d
Intra-abd 5 or 7d = 10
7d = 10 or 14d GNB ... #Stewardship #InfectiousDiseases
Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
malignancy Pathophysiology ... • GH stimulates ... level (↑Sens) - GH ... (Lanreotide) ± GH ... Endocrinology #Treatment #Pathophysiology
Iron Deficiency in Congestive Heart Failure (CHF)

Iron deficiency (ID) in heart failure is a common comorbidity
(kg) x (target Hgb ... — actual Hgb) x ... #pharmacology #pathophysiology
Oxygen Delivery Equation
DO2 = CO x {(1.39 x Hb x sO2) + (PaO2 x 0.03)}
DO2 =
CO x {(1.39 x Hb ... Output in L/min Hb ... = Hemoglobin (Hb ... is w/ apples = Hb ... Delivery #Equation #pathophysiology
Leishmaniasis Life Cycle
1) Sandfly takes a blood meal (injects promastigote stage into the skin)
Human Stages:
2) Promastigotes
LifeCycle #diagnosis #pathophysiology ... #infectiousdiseases
Oxyhemoglobin Dissociation Curve 

Left Shift - decreased unloading of O2 at tissue level (i.e.  increased
blood cells - Hb ... Dissociation #Curve #Pathophysiology