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diagnosis differential algorithm management prolonged pt aptt bleeding bruising intravascular oncology polycythemia anemia aplastic classification dic disorders disseminated erythrocytosis extravascular
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... Prolonged PTT, Normal ... Prolonged PTT, Normal ... Diagnosis #Algorithm #Causes ... #Hematology #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Destruction • Abnormal ... • Vasculitis Coagulation ... Diagnosis #Algorithm #Causes ... #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Drug-induced AIHA - Abnormal ... Hgb & Hgb Defects ... Diagnosis #Algorithm #Causes ... #Hematology
Erythrocytosis - Polycythemia Differential Diagnosis Algorithm Elevated Hemoglobin: • Males: Hb > 16.5 g/dL/HCT ≥ 49% •
Hemoglobin: • Males: Hb ... 49% • Females: Hb ... Polycythemia - Acquired Causes ... ), TEMPI (VEGF normal ... Diagnosis #Algorithm #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... Jcortesizaguirr #Abnormal ... #differential #hematology ... #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia - Normal ... Treat primary cause ... - APTT < 1.5 x normal ... #diagnosis #causes ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Causes include : ... Pre-analytical cause ... amyloidosis #Abnormal ... #differential #hematology ... #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... PT/ABNORMAL PTT ... intravascular coagulation ... discern these causes ... Differential #Diagnosis #Hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... Better call hematology ... exogenous, EPO levels: normal ... about secondary causes ... Algorithm #workup #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... - Hepatitis, eosinophilic ... syndrome (MDS) (normal ... megakaryocytes and a normal ... Anemia #oncology #hematology
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