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systemic ana antinuclear pain symptoms algorithm antibodies arthritis autoantibodies comparison monoarthritis monoarticular patterns polyarthritis polyarticular vasculitis aortitis approach arthropathies arthropathy
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... erythematosus ( ... Syndrome (SS), Polymyositis ... ANA #patterns #rheumatology ... #diagnosis #differential
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Associated with Joint ... Antiphospholipid-antibody syndrome ... lesions • Discoid lupus ... #skin #rashes #differential ... #diagnosis #rheumatology
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
- Differential Diagnosis ... arthritis - (Reiter’s syndrome ... Erythematosus ( ... SLE), should have ... #Disorders #msk
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
(SLE) General: ... Demyelinating syndromes ... #erythematosus # ... signs #symptoms ... #diagnosis #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... permanent alopecia Differential ... Arthritis: • Joint ... arthropathy • 90% joints ... #Diagnosis #Rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Diagnosis and Lupus ... #Erythematosus ... #signs #symptoms ... #rheumatology
Inflammatory Joint Pain - Differential Diagnosis Algorithm Monoarticular • Gout (Podagra, Tophi) • Pseudogout • Early
Pain - Differential ... Arthritis • Systemic Lupus ... Erythematosus ... Sicca) Syndrome ... Inflammatory #JointPain #MSK
Antinuclear antibodies and Systemic lupus Anti-dsDNA 60-80% Association with disease activity (when with Farr assay) and lupus nephritis. Can
Farr assay) and lupus ... overlap syndromes ... #erythematosus ... #diagnosis #rheumatology ... #table #ANA
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
erythematosus ( ... Syndrome (SS), Polymyositis ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
spondyloarthropathies, lupus ... Chronic = RA, SLE ... #Joint #Pain #MSK ... #rheumatology # ... approach #workup #differential
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