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differential management signs sle erythematosus oncology autoantibodies classification comparison disease hematology treatment algorithm aortitis arteritis arthritis associations chronic cll cryoglobulinemia
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Lupus (SLE) General ... Butterfly rash, Vasculitis ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
rapidly progressing GN ... and branches • GCA ... lupus erythematosus ... Symptoms (Sx) in ... #rheumatology #
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Glomerulonephritis #Vasculitis ... #differential #diagnosis ... #algorithm #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Symptoms (SX) in ... Elevated ESR and CRP GCA ... develop in pts with GCA ... • Progressive symptoms ... #Rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
- Differential Diagnosis ... Cell Arteritis (GCA ... Arthritis (RA), Systemic ... lupus erythematosus ... #rheumatology
Autoantibodies in Rheumatology • Lupus (SLE): ANA (anti-nuclear antibody), dsDNA (double-stranded DNA), Anti-Smith, Anti-Ro (SSA) and
• Lupus (SLE): ... • Scleroderma (Systemic ... Polymerase Ill • ANCA Vasculitis ... #diagnosis #associations ... #table
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... - Hemolytic anemia ... Lupusreference #SLE #Systemic ... #signs #symptoms ... #differential #rheumatology
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
inflammatory vasculitis ... = vasculitis vs ... complaints- anemia ... them, but urgent rheumatology ... Temporal #Signs #Symptoms
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... months to years) Systemic ... sle #comparison #table ... #rheumatology # ... diagnosis #management
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