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management erythematosus systemic joint signs pain algorithm vasculitis ana antinuclear approach classification comparison disease disorders druginduced hematology monoarthritis monoarticular neurology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus (SLE ... Juvenile Idiopathic Arthritis ... #Antinuclear #Antibodies ... ANA #patterns #rheumatology ... #diagnosis #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
: - Arthritis ... Auto-Antibodies ... Diagnosis and Lupus ... autoantibodies #signs #symptoms ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Antibody refers to antibodies ... context of other symptoms ... ANA #patterns #rheumatology ... #diagnosis #differential
Joint Disorders - Differential Diagnosis Algorithm Monoarthritis • Septic • Crystalline - Gout
Joint Disorders - Differential ... Diagnosis Algorithm ... Erythematosus (SLE ... should have other symptoms ... Joint #Disorders #msk
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
(SLE): Musculoskeletal ... - Arthralgia, Arthritis ... #MSK #Musculoskeletal ... pathophysiology #signs #symptoms ... #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... , Arthritis, myalgia ... • Immunologic Workup ... #table #rheumatology ... #diagnosis #management
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
Aortitis - Differential ... Diagnosis Framework ... (RA), Systemic lupus ... erythematosus (SLE ... #Diagnosis #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Complement: Post-strep GN ... , Lupus Nephritis ... Purpura Anti-GBM antibodies ... #diagnosis #algorithm ... #rheumatology
EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus Clinical Domains: • Constitutional domain: Fever • Cutaneous domain: Non-scarring
• Arthritis domain ... Highly specific antibodies ... Classification #Criteria #SLE ... Erythematosus #diagnosis ... #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash • SLE ... IBD • RA • SLE ... lesions • Discoid lupus ... #skin #rashes #differential ... #diagnosis #rheumatology
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